Medicine and Medical Sciences Research

Cyclophosphamide is responsible for long-lasting defects in the hematopoietic stem cells and the rat immune system. The planned studies to determine whether chloramphenicol further weakened the already defective hematopoietic stem cells of rats pretreated with cyclophosphamide, and the unexpectedly observed that lymphomas formed in relatively high incidence by rats provided injections of the combination of cyclophosphamide and chloramphenicol. For certain affected rats leukocytosis with lymphoblasts occurred in the peripheral blood. The malignant cell is thymic lymphoblast. Ten of the 40 rat, which taken both chloramphenicol and cyclophosphamide raised lymphomas. Ten of the remaining 30 rat, which treated with chloramphenicol developed lymphomas. And the remaining 20 rat of ten, which consumed only cyclophosphamide developed lymphomas. The lymphoma doesn’t develop in control rat during the experimental periods. The present studies conclude that both cyclophosphamide and chloramphenicol can cause lymphomas in rats that are not known to spontaneously develop these. The combination of both Cyclophosphamide and Chloramphenicol increased the incidence and the progression of the disease accelerated.